Why the study?
Are there population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patients?
Are there population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patients?
Japanese patients exhibit significantly higher S-warfarin clearance than Caucasian patients with the same CYP2C9*1 wild-type genotype, indicating unknown factors contribute to interpopulation variability in warfarin metabolism.
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May warrant ethnicity-specific warfarin dosing caution; leaves open unidentified factors driving inter-ethnic clearance differences.
Takahashi et al. (2003) studied this question.
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