Why the study?
Does ALDH2 overexpression prevent chronic alcohol intake-induced cardiac contractile dysfunction and autophagy in mice?
Population
Adult male wild-type friendly virus B mice and transgenic mice overexpressing ALDH2 driven by chicken…
Comparison
ALDH2 overexpression in the setting of a 12-week… vs Wild-type FVB mice on 4% ethanol diet, and…
Design
Preclinical
Follow-up
12 weeks
Authors
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ALDH2 overexpression may attenuate alcohol cardiomyopathy in mice; leaves open human translation and requires clinical validation.
Does ALDH2 overexpression prevent chronic alcohol intake-induced cardiac contractile dysfunction and autophagy in mice?
ALDH2 overexpression protects against alcoholic cardiomyopathy and contractile dysfunction in mice by inhibiting autophagy via restoration of the Akt-mTOR-STAT3-Notch signaling cascade.
Ge et al. (2011) studied this question.
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