Why the study?
Does angiotensin II-induced hypertension accelerate the development of atherosclerosis in apoE-deficient mice?
Population
apoE-deficient mice on either standard chow or an atherogenic diet
Comparison
Angiotensin II (0.7 mg x kg x d SC) administered… vs Control on standard chow or atherogenic diet…
Design
Preclinical
Follow-up
8 weeks
Authors
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No practice change; leaves open Ang II role in human atherosclerosis beyond hypertension.
Does angiotensin II-induced hypertension accelerate the development of atherosclerosis in apoE-deficient mice?
Angiotensin II-induced hypertension profoundly accelerates atherosclerosis development in apoE-deficient mice regardless of diet, an effect not seen with norepinephrine-induced hypertension.
Weiss et al. (2001) studied this question.
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