Why the study?
Does deoxycorticosterone acetate salt-induced hypertension accelerate atherosclerosis in ApoE-/- mice, and can it be inhibited by RAAS blockade or blood pressure reduction?
Population
Apolipoprotein E-deficient (ApoE-/-) mice on either a low- or high-fat diet
Comparison
Deoxycorticosterone acetate salt-induced… vs Untreated hypertensive ApoE-/- mice and/or…
Design
Preclinical
Authors
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Should not change practice; hypothesis-generating for RAAS inhibition or BP reduction in low-renin atherosclerosis models, pending human trials.
Does deoxycorticosterone acetate salt-induced hypertension accelerate atherosclerosis in ApoE-/- mice, and can it be inhibited by RAAS blockade or blood pressure reduction?
Even in low-renin hypertension, local generation of angiotensin II within the arterial wall and mechanical effects of elevated blood pressure contribute to accelerated atherosclerosis, which can be mitigated by RAAS inhibition or blood pressure reduction.
Weiss et al. (2007) studied this question.
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