Why the study?
Does L-NMMA reduce basal and stimulated forearm blood flow in healthy men?
Population
32 healthy men
Comparison
N-monomethyl-L-arginine infused via the brachial… vs Baseline flow and nitroprusside
Design
Other
Authors
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Supports forearm NO blockade models in research; leaves open clinical translation to endothelial therapies.
Does L-NMMA reduce basal and stimulated forearm blood flow in healthy men?
L-NMMA effectively inhibits basal and stimulated NO-dependent vasodilation in the human forearm, with compensatory mechanisms involving prostaglandins or NO at high acetylcholine doses.
Dawes et al. (2001) studied this question.
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