Why the study?
Does L-NMMA inhibit kinin-induced vasodilation in the human forearm?
Population
16 healthy male volunteers (8 for bradykinin infusion, 8 for substance P infusion)
Comparison
Intra-arterial co-infusion of L-NMMA with… vs L-NMMA vehicle co-infused with bradykinin or…
Design
Other
Follow-up
6 minutes
Authors
Loading...
May support kinin agonists for endothelial NO studies; leaves open outcome validation before clinical adoption.
Does L-NMMA inhibit kinin-induced vasodilation in the human forearm?
Vasodilator responses to bradykinin and substance P in the human forearm are mediated in part via the L-arginine/NO pathway, suggesting their utility as agonists to study endothelial function.
Cockcroft et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: