September 1, 1990British Journal of PharmacologyOpen Access

Inhibitory role of endothelium‐derived relaxing factor in rat and human pulmonary arteries

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Population

Rat and human pulmonary arteries in vitro

Comparison

L-NMMA pretreatment vs D-NMMA, L-arginine, D-arginine, endothelium…

Design

Preclinical

Authors

DCDavid CrawleyForeign and Commonwealth Office SLS. F. LiuLung Institute TETimothy W. EvansNational Health Service

Discussion

Member takes

Implication

Hypothesis-generating for pulmonary endothelial modulation; leaves open clinical translation to human vascular disease.

Structured PICO

Population

Rat and human pulmonary arteries in vitro

Intervention

L-NMMA (NG-monomethyl-L-arginine) pretreatment (10-300 microM)

Comparator

D-NMMA, L-arginine, D-arginine, endothelium removal, or no pretreatment

Outcome

Vascular relaxation and contraction responses (acetylcholine-induced relaxation, sodium nitroprusside-induced relaxation, phenylephrine-induced vasoconstriction)surrogate

Endothelium-derived relaxing factor mediates relaxation and acts as a physiological brake against vasoconstriction in pulmonary vessels.

Cite This Study

Crawley et al. (1990) studied this question.

synapsesocial.com/papers/6a8bd1192ff0ab4f91e95bfe https://doi.org/10.1111/j.1476-5381.1990.tb12107.x

View Full Paper

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Bookmark

Inhibitory role of endothelium‐derived relaxing factor in rat and human pulmonary arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibitory role of endothelium‐derived relaxing factor in rat and human pulmonary arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider