October 1, 1990Circulation ResearchOpen Access

NG-monomethyl L-arginine inhibits endothelium-derived relaxing factor-stimulated cyclic GMP accumulation in cocultures of endothelial and vascular smooth muscle cells by an action specific to the endothelial cell.

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Why the study?

Does NG-monomethyl L-arginine (LNMMA) inhibit EDRF-stimulated cyclic GMP accumulation in bovine endothelial and vascular smooth muscle cells?

Population

Bovine pulmonary artery endothelial cells and vascular smooth muscle cells in cocultures and superfused…

Comparison

NG-monomethyl L-arginine (LNMMA) 30-300 microM vs Absence of LNMMA (control buffer)

Design

Preclinical

Authors

RJRoger A. JohnsJohns Hopkins University MPM J PeachLancaster University JLJoel LindenCross-Cutting Cardiology

Discussion

Member takes

Implication

LNMMA selectively blocks EDRF-driven cGMP in endothelial-smooth muscle cocultures; leaves open its value as an in vivo research tool or clinical candidate.

Structured PICO

Does NG-monomethyl L-arginine (LNMMA) inhibit EDRF-stimulated cyclic GMP accumulation in bovine endothelial and vascular smooth muscle cells?

Population

Bovine pulmonary artery endothelial cells and vascular smooth muscle cells in cocultures and superfused columns

Intervention

NG-monomethyl L-arginine (LNMMA) 30-300 microM

Comparator

Absence of LNMMA (control buffer)

Outcome

Cyclic GMP accumulation in vascular smooth muscle cellssurrogate

LNMMA acts as a specific inhibitor of EDRF production or release at the level of the endothelial cell.

Cite This Study

Johns et al. (1990) studied this question.

synapsesocial.com/papers/6a89b7634c30e1095aec896a https://doi.org/10.1161/01.res.67.4.979

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Implication

LNMMA selectively blocks EDRF-driven cGMP in endothelial-smooth muscle cocultures; leaves open its value as an in vivo research tool or clinical candidate.

NG-monomethyl L-arginine inhibits endothelium-derived relaxing factor-stimulated cyclic GMP accumulation in cocultures of endothelial and vascular smooth muscle cells by an action specific to the endothelial cell.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

NG-monomethyl L-arginine inhibits endothelium-derived relaxing factor-stimulated cyclic GMP accumulation in cocultures of endothelial and vascular smooth muscle cells by an action specific to the endothelial cell.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider