Astemizole-derived fluorescent probes successfully label hERG potassium channels in living cells, offering a potential tool for cardiotoxicity screening and tumor imaging.
The detection and imaging of hERG potassium channels in living cells can provide useful information for hERG-correlation studies. Herein, three small-molecule fluorescent probes, based on the potent hERG channel inhibitor astemizole, for the imaging of hERG channels in hERG-transfected HEK293 cells (hERG-HEK293) and human colorectal cancer cells (HT-29), are described. These probes are expected to be applied in the physiological and pathological studies of hERG channels.
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Wang et al. (2016) studied this question.
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