Key result
Astemizole-based fluorescent probes enable hERG potassium channel imaging at the nanomolar level with acceptable toxicity.
Astemizole-based fluorescent probes enable nanomolar-level imaging of hERG potassium channels, offering a potential tool for hERG screening systems.
These hERG probes enable nanomolar cell imaging; leaves open validation for cardiotoxicity screening systems.
) for human ether-a-go-go-related gene (hERG) potassium channel were developed herein. These probes have reasonable fluorescence properties, acceptable cell toxicity, and potent inhibitory activity, all of which contribute to cell imaging at the nanomolar level. Overall, these probes have the potential for setting up a screening system for hERG channels.
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Zhang et al. (2019) studied this question. Astemizole-based fluorescent probes demonstrated acceptable cell toxicity and potent inhibitory activity, enabling hERG potassium channel imaging at the nanomolar level.
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