Why the study?
Does enalapril compared to hydrochlorothiazide plus propranolol alter the relationship between blood pressure/heart rate changes and echocardiographic left ventricular indices in moderate to severe hypertensive patients with LVH?
Population
15 moderate to severe hypertensive patients with established left ventricular hypertrophy
Comparison
Enalapril 10 to 40 mg/day for 26 weeks vs Hydrochlorothiazide 50 mg plus propranolol 80 to…
Design
RCT, randomized, double-blind
Follow-up
26 weeks
Authors
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Links BP/HR reductions to LV structural changes with either regimen; extends evidence on hemodynamic drivers of remodeling in hypertensive LVH.
Does enalapril compared to hydrochlorothiazide plus propranolol alter the relationship between blood pressure/heart rate changes and echocardiographic left ventricular indices in moderate to severe hypertensive patients with LVH?
Chronic therapy with enalapril or hydrochlorothiazide plus propranolol in hypertensive patients with LVH results in distinct correlations between hemodynamic changes and regional left ventricular structural changes.
Fernandez et al. (1984) studied this question.
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