Why the study?
Does enalapril improve left ventricular diastolic properties in patients with chronic severe left ventricular systolic dysfunction (LVEF ≤35%)?
Population
42 patients with chronic severe left ventricular systolic dysfunction
Comparison
Enalapril 10 mg BID vs Placebo
Design
RCT, randomized
Follow-up
average 12.4 months
Authors
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Supports enalapril to attenuate remodeling in severe systolic dysfunction; extends RCT evidence to LV volumes and stiffness.
Does enalapril improve left ventricular diastolic properties in patients with chronic severe left ventricular systolic dysfunction (LVEF ≤35%)?
Enalapril therapy prevents or partially reverses progressive left ventricular dilatation and decreases in chamber stiffness in patients with severe systolic left ventricular dysfunction, suggesting partial reversal of remodeling.
Pouleur et al. (1993) studied this question.
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