Key result
Enalapril added to frusemide for 3 months in 11 heart failure patients reduced ventricular volume and increased ejection fraction, reshaping the ventricle without improving intrinsic pump function.
Why the study?
Does enalapril improve pump function and cardiac contractility in patients with chronic congestive heart failure?
Population
11 patients with coronary artery disease and chronic heart failure
Comparison
Enalapril added to frusemide medication for… vs Baseline (before treatment)
Design
Cohort
Follow-up
3 months
Authors
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Enalapril may promote remodeling without contractility gains in small HF cohorts; leaves open confirmation in randomized trials.
Observational (n=11)
Does enalapril improve pump function and cardiac contractility in patients with chronic congestive heart failure?
In patients with chronic heart failure, enalapril reshapes the ventricle and improves clinical condition without improving intrinsic pump function.
Baur et al. (1991) conducted an observational in coronary artery disease and chronic heart failure (n=11). enalapril vs. Baseline (before treatment) was evaluated on Left ventricular pressure and volume, ejection fraction, and hormone concentrations. Enalapril added to frusemide for 3 months in 11 heart failure patients reduced ventricular volume and increased ejection fraction, reshaping the ventricle without improving intrinsic pump function.
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