Key result
A review of digoxin's pharmacologic actions and recent trial results suggests it may continue to be an effective treatment for heart failure despite the introduction of newer therapies.
Why the study?
Does digoxin remain an effective treatment for heart failure?
Does digoxin remain an effective treatment for heart failure?
This review argues that digoxin may still have a role in the management of heart failure despite the introduction of newer mortality-reducing therapies.
May support adjunctive digoxin consideration in select HF patients; leaves open confirmation by contemporary randomized trials.
Digoxin has been the cornerstone of the treatment of heart failure for more than 2 centuries. Now that newer therapies have been introduced that reduce the mortality rate in heart failure and recent trials have failed to prove the same for digoxin, its use has significantly decreased. But a careful review of the multiple pharmacologic actions of digoxin and closer analysis of the results of recent trials suggest that digoxin may in fact continue to be an effective treatment for heart failure.
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Pervaiz et al. (2006) conducted a review in Heart failure. Digoxin was evaluated. A review of digoxin's pharmacologic actions and recent trial results suggests it may continue to be an effective treatment for heart failure despite the introduction of newer therapies.
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