What is the clinical evidence from this study?

Study design: Other. Population: Pacing-induced cardiomyopathy. Intervention: Levosimendan vs. Baseline (pre-pacing). Primary outcome: Left ventricular systolic and diastolic function (Mw, +dP/dt, tau, dL/dt, Kp) (p=< 0.05).

What question did this study set out to answer?

To investigate the effects of levosimendan on left ventricular mechanical actions in dogs with pacing-induced cardiomyopathy.

May 1, 1997Journal of Cardiovascular Pharmacology

Levosimendan Enhances Left Ventricular Systolic and Diastolic Function in Conscious Dogs with Pacing-Induced Cardiomyopathy

Q: What are the key findings of this study?

Levosimendan significantly improved systolic and diastolic function in dogs with pacing-induced cardiomyopathy, increasing Mw from 54 to 98 mm Hg (p < 0.05).

Q: What question did this study set out to answer?

To investigate the effects of levosimendan on left ventricular mechanical actions in dogs with pacing-induced cardiomyopathy.

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Key result

Levosimendan significantly improved systolic and diastolic function in dogs with pacing-induced cardiomyopathy, increasing Mw from 54 to 98 mm Hg (p < 0.05).

Why the study?

Does levosimendan improve left ventricular systolic and diastolic function in conscious dogs with pacing-induced cardiomyopathy?

Population

Conscious dogs chronically instrumented for measurement of aortic and LV pressure, +dP/dt, subendocardial…

Comparison

Levosimendan vs Baseline measurements before levosimendan…

Design

Preclinical

Follow-up

22 +/- 2 days (pacing duration)

Authors

PPPaul S. PagelStructural Heart Disease MMMartin McgoughMedical College of Wisconsin DHDouglas A. HettrickElectrophysiology

Discussion

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Implication

Should not change clinical practice; hypothesis-generating for levosimendan effects in cardiomyopathy.

Key Points

To investigate the effects of levosimendan on left ventricular mechanical actions in dogs with pacing-induced cardiomyopathy.
Conscious dogs chronically instrumented for measuring aortic and left ventricular pressure, +dP/dt, and cardiac output.
Dogs received levosimendan before and during rapid ventricular pacing (240 beats/min for approximately 3 weeks).
Parameters evaluated included myocardial contractility, diastolic function, and hemodynamic indices.
Levosimendan significantly increased Mw from 54 +/- 3 to 98 +/- 6 mm Hg and +dP/dt from baseline, p < 0.05.
Improved diastolic function with decreased tau (66 +/- 4 to 52 +/- 3 ms) and Kp (1.14 +/- 0.14 to 0.71 +/- 0.03 mm-1).
No significant change in heart rate or myocardial oxygen consumption after pacing.

Structured PICO

Does levosimendan improve left ventricular systolic and diastolic function in conscious dogs with pacing-induced cardiomyopathy?

Population

Conscious dogs chronically instrumented for measurement of aortic and LV pressure, +dP/dt, subendocardial segment length, and cardiac output, before and after development of pacing-induced cardiomyopathy (paced at 240 beats/min for 22 +/- 2 days).

Intervention

Levosimendan (12- or 24-microgram/kg loading dose and 0.2 or 0.4 microgram/kg/min infusion)

Comparator

Baseline measurements before levosimendan administration (within-subject comparison)

Outcome

Left ventricular systolic function (Mw, +dP/dt) and diastolic function (tau, dL/dt, Kp)surrogate

Main Result

p-value: p=< 0.05

Levosimendan produces positive inotropic and lusitropic effects without altering heart rate or myocardial oxygen consumption in a canine model of pacing-induced cardiomyopathy.

Cite This Study

Pagel et al. (1997) studied Pacing-induced cardiomyopathy. Levosimendan vs. Baseline (pre-pacing) was evaluated on Left ventricular systolic and diastolic function (Mw, +dP/dt, tau, dL/dt, Kp) (p=< 0.05). Levosimendan significantly improved systolic and diastolic function in dogs with pacing-induced cardiomyopathy, increasing Mw from 54 to 98 mm Hg (p < 0.05).

synapsesocial.com/papers/6a19bb6b443d3ecd7cdef1d0 https://doi.org/10.1097/00005344-199705000-00001

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Levosimendan Enhances Left Ventricular Systolic and Diastolic Function in Conscious Dogs with Pacing-Induced Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Levosimendan Enhances Left Ventricular Systolic and Diastolic Function in Conscious Dogs with Pacing-Induced Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider