What does this research mean for the field?

Increased QT interval dispersion (QTd), but not corrected QT (QTc), is a significant predictor of 15-year cardiovascular mortality in patients with type 2 diabetes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 2, 2012Diabetes CareOpen Access

Increased QT Interval Dispersion Predicts 15-Year Cardiovascular Mortality in Type 2 Diabetic Subjects

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Why the study?

Does increased QT interval dispersion predict cardiovascular mortality in type 2 diabetic patients?

Population

1,357 type 2 diabetic patients from the Casale Monferrato Study (Italy), including 580 male and 779 female.

Comparison

Increased QT interval dispersion and prolonged QTc vs Normal QT interval dispersion and normal QTc

Design

Cohort, R-R and QT intervals were measured blindly by two observers

Follow-up

15 years

Authors

SGSara GiuntiMerck & Co., Inc., Rahway, NJ, USA (United States)GGGabriella GrudenGeneral / Preventive / Lipids PFPaolo FornengoDepartment of Medical Sciences

Discussion

Member takes

Implication

Prolonged QTd may aid CV risk stratification in T2D; leaves open incremental value and need for prospective validation before practice change.

Structured PICO

Does increased QT interval dispersion predict cardiovascular mortality in type 2 diabetic patients?

Population

1,357 type 2 diabetic patients from the Casale Monferrato Study (Italy), including 580 male and 779 female.

Intervention

Increased QT interval dispersion (QTd >0.08 s) and prolonged QTc (>0.44 s)

Comparator

Normal QT interval dispersion (QTd ≤0.08 s) and normal QTc (≤0.44 s)

Outcome

All-cause and cardiovascular mortality 15 years after baselinehard clinical

Increased QT interval dispersion is an independent predictor of long-term cardiovascular mortality in type 2 diabetic patients, offering a noninvasive and low-cost tool for risk stratification.

Limitations

Manual assessment of the QT interval
Possibility that changes in QTc/QTd abnormalities occurred during follow-up cannot be excluded
Potential overadjustment bias in the fully adjusted model

Cite This Study

Giunti et al. (2012) studied this question.

synapsesocial.com/papers/6a19bcd37081f56b37df01a1 https://doi.org/10.2337/dc11-1397

Topics

Women and heart disease

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Bookmark

Implication

Prolonged QTd may aid CV risk stratification in T2D; leaves open incremental value and need for prospective validation before practice change.

Increased QT Interval Dispersion Predicts 15-Year Cardiovascular Mortality in Type 2 Diabetic Subjects

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Increased QT Interval Dispersion Predicts 15-Year Cardiovascular Mortality in Type 2 Diabetic Subjects

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider