What does this research mean for the field?

Women with polycystic ovary syndrome have elevated endothelin-1 levels compared to healthy controls, and six months of metformin therapy significantly reduces these levels while improving hormonal and metabolic profiles. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 2001The Journal of Clinical Endocrinology & Metabolism

Increased Endothelin-1 Levels in Women with Polycystic Ovary Syndrome and the Beneficial Effect of Metformin Therapy

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Why the study?

Does metformin reduce endothelin-1 levels and improve metabolic profiles in women with polycystic ovary syndrome?

Population

60 women total: 43 women with polycystic ovary syndrome and 17 healthy, normal cycling, age-matched control…

Comparison

Metformin 1700 mg daily for 6 months vs Healthy, normal cycling, age-matched women…

Design

Cohort

Follow-up

6 months

Authors

EDEvanthia Diamanti‐KandarakisHygeia Hospital GSGiovanna SpinaLaiko General Hospital of Athens CKChryssa KouliLaiko General Hospital of Athens

Discussion

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Implication

Metformin-associated endothelin-1 reductions in PCOS may signal vascular effects; leaves open whether this improves clinical outcomes.

Structured PICO

Does metformin reduce endothelin-1 levels and improve metabolic profiles in women with polycystic ovary syndrome?

Population

60 women total: 43 women with polycystic ovary syndrome (23 obese, mean age 24.3 +/- 4.6 yr, BMI 35 +/- 5.6 kg/m2; 20 nonobese, mean age 24.1 +/- 3.6 yr, BMI 21.8 +/- 2.5 kg/m2) and 17 healthy, normal cycling, age-matched control women (7 obese, 10 nonobese). A subgroup of 20 PCOS women (10 obese, 10 nonobese) received the intervention.

Intervention

Metformin 1700 mg daily for 6 months

Comparator

Healthy, normal cycling, age-matched women (for baseline cross-sectional comparison); baseline values before therapy (for the 6-month metformin intervention subgroup)

Outcome

Plasma endothelin-1 levelssurrogate

Metformin therapy reduces elevated endothelin-1 levels and improves hormonal and metabolic profiles in women with polycystic ovary syndrome, potentially mitigating their cardiovascular risk.

Cite This Study

Diamanti‐Kandarakis et al. (2001) studied this question.

synapsesocial.com/papers/6a19bf533e4c9aaeb7f660f8 https://doi.org/10.1210/jcem.86.10.7904

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Increased Endothelin-1 Levels in Women with Polycystic Ovary Syndrome and the Beneficial Effect of Metformin Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased Endothelin-1 Levels in Women with Polycystic Ovary Syndrome and the Beneficial Effect of Metformin Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider