Key result
A literature review indicates a bidirectional relationship between hypertension and endothelial dysfunction, where endothelial damage acts as both a consequence and a potential cause of elevated BP.
Why the study?
Endothelial damage is a major target organ consequence of hypertension, but defects in endothelial structure and function are also considered potential causes of increased blood pressure.
This literature review explores the bidirectional causal relationship between hypertension and endothelial dysfunction.
Does not support routine endothelial assessment in hypertension care; leaves open bidirectional causality for prospective interventional trials.
Hypertension remains a pandemic of the 21st century, being a major factor of premature death. The introduction of imaging methods into clinical practice revealed a high prevalence of target organ damage mediated by hypertension. One of the systemic target organs in hypertension is endothelium. Its damage plays an important role in the initiation of the cardiovascular disease continuum. On the other hand, structure and function defects of the endothelium is considered as a possible reason for the increase in blood pressure. This literature review systematizes data on a causal relationship between hypertension and endothelial dysfunction, and discusses the direction of further study of vascular endothelium function.
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Gorshkov et al. (2019) conducted a review in Hypertension and endothelial dysfunction. A literature review indicates a bidirectional relationship between hypertension and endothelial dysfunction, where endothelial damage acts as both a consequence and a potential cause of elevated BP.
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