Why the study?
Does age affect the haemodynamic responsiveness to alpha-adrenoceptor agonists and antagonists in healthy subjects?
Does age affect the haemodynamic responsiveness to alpha-adrenoceptor agonists and antagonists in healthy subjects?
Aging may be associated with a reduction in vascular responsiveness to alpha-adrenoceptor activation, as evidenced by a higher dose of phenylephrine required to raise blood pressure in elderly subjects.
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No immediate dosing changes for alpha-agonists; extends beta-receptor observations but leaves open relevance in patients.
Elliott et al. (1982) studied this question.
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