Key result
Volume expansion with 500 mL normal saline increased femoral dP/dtmax by 46% (mean change 510.6 mm Hg·s, p=0.005) in preload-dependent patients, but not in preload-independent patients.
Why the study?
The study evaluated the preload dependence of femoral dP/dtmax during volume expansion in critically ill patients who were preload dependent versus independent.
Does fluid infusion of 500 mL normal saline alter femoral dP/dtmax in critically ill patients with acute circulatory failure?
Observational (n=25)
Yes
Does fluid infusion of 500 mL normal saline alter femoral dP/dtmax in critically ill patients with acute circulatory failure?
Femoral dP/dtmax is highly dependent on preload and arterial stiffness, demonstrating it is not a reliable load-independent marker of left ventricular contractility in critically ill patients.
Femoral dP/dtmax should not yet guide contractility assessment in critically ill patients; this cohort study leaves open its load independence pending randomized validation.
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Vaquer et al. (2020) conducted an observational in Acute circulatory failure (n=25). Fluid infusion (normal saline) vs. Preload-independent patients was evaluated on Change in femoral dP/dtmax (p=0.005). Volume expansion with 500 mL normal saline increased femoral dP/dtmax by 46% (mean change 510.6 mm Hg·s, p=0.005) in preload-dependent patients, but not in preload-independent patients.
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