What does this research mean for the field?

One year of cholesterol-lowering therapy with statins in patients with familial hypercholesterolaemia significantly decreases arterial wall stiffness in the common femoral artery and arterial wall thickness in the common carotid artery. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 2000European Journal of Clinical Investigation

The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia

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Why the study?

Does cholesterol lowering therapy with statins improve artery wall stiffness and intima media thickness in patients with familial hypercholesterolaemia?

Population

45 patients with familial hypercholesterolaemia with untreated LDL cholesterol concentration > 9 mmol L

Comparison

Cholesterol lowering therapy with statins… vs Baseline (before therapy)

Design

Cohort

Follow-up

1 year

Authors

SSmildeRadboud University Nijmegen VBVan Den Berkmortel WWollersheim

Discussion

Member takes

Implication

Statin effects on arterial properties in familial hypercholesterolemia should not yet alter practice; leaves open translation to cardiovascular outcomes.

Structured PICO

Does cholesterol lowering therapy with statins improve artery wall stiffness and intima media thickness in patients with familial hypercholesterolaemia?

Population

45 patients with familial hypercholesterolaemia (mean age 46+/-10 years) with untreated LDL cholesterol concentration > 9 mmol L(-1)

Intervention

Cholesterol lowering therapy with statins (simvastatin, atorvastatin 40-80 mg day(-1)) for one year

Comparator

Baseline (before therapy)

Outcome

Artery wall stiffness (distensibility and compliance of the common carotid artery and common femoral artery) and intima media thickness (IMT of the CCA, bulb, internal carotid artery and CFA)surrogate

One year of intensive statin therapy in patients with familial hypercholesterolemia significantly reduces femoral artery wall stiffness and carotid artery intima-media thickness.

Cite This Study

Smilde et al. (2000) studied this question.

synapsesocial.com/papers/6a19c8ae3f3ec013f0df0f72 https://doi.org/10.1046/j.1365-2362.2000.00654.x

Topics

PCSK9 inhibitors

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Implication

Statin effects on arterial properties in familial hypercholesterolemia should not yet alter practice; leaves open translation to cardiovascular outcomes.

The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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