Key result
Arterial stiffness is moderately correlated with prolonged atrial conduction in patients with OSA.
Why the study?
Prolonged P-wave duration indicates atrial conduction delay and precedes AF in OSA, while arterial stiffness measured by CAVI is elevated in OSA; the relationship between CAVI and PWD in patients with OSA remains to be clarified.
Is increased arterial stiffness associated with atrial conduction delay in patients with obstructive sleep apnea?
Cross-Sectional (n=300)
No
Is increased arterial stiffness associated with atrial conduction delay in patients with obstructive sleep apnea?
Effect estimate: r = 0.478
p-value: p=<0.001
In patients with obstructive sleep apnea, increased arterial stiffness is independently associated with atrial conduction delay, suggesting a mechanism for increased atrial fibrillation risk.
Supports potential AF mechanism via stiffness in OSA; hypothesis-generating and should not yet change practice.
Aim: Prolonged P-wave duration (PWD), which indicates atrial conduction delay, is a potent precursor of atrial fibrillation (AF) that may be induced by obstructive sleep apnea (OSA). The cardio-ankle vascular index (CAVI), which is an arterial stiffness parameter, is elevated in patients with OSA; moreover, an increased CAVI is associated with atrial conduction delay through left atrium enlargement in association with left ventricular diastolic dysfunction. We aimed to examine the relationship between the CAVI and PWD in patients with OSA. Methods: We included patients with a sinus rhythm who underwent overnight polysomnography. We measured the PWD and CAVI on standard 12-lead electrocardiograms; further, we analyzed the relationship between PWD and CAVI. Results: We analyzed data from 300 participants (men, 89.0%; mean age, 52.3 ± 13.1 years; and body mass index, 26.2 ± 3.9 kg/m 2 ). The mean PWD was 104.4 ± 10.4 ms while the mean CAVI was 7.5 ± 1.5. PWD was significantly correlated with CAVI (r = 0.478, p < 0.001); additionally, PWD and CAVI were directly associated with OSA severity ( p = 0.002 and p = 0.002, respectively). Multivariate regression analysis revealed an independent significant correlation of PWD and CAVI with OSA severity. Conclusion: In patients with OSA, an increase in arterial stiffness is associated with atrial conduction delay.
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Ueda et al. (2023) conducted a cross-sectional in Obstructive Sleep Apnea (n=300). Arterial stiffness (Cardio-ankle vascular index) was evaluated on Correlation between P-wave duration (PWD) and cardio-ankle vascular index (CAVI) (r = 0.478, p=<0.001). In patients with obstructive sleep apnea, P-wave duration was significantly correlated with the cardio-ankle vascular index (r = 0.478, p < 0.001), indicating that increased arterial stiffness is associated with atrial conduction delay.
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