Key result
New-onset tumors in severe CAD linked to ~134% higher arrhythmia risk.
Why the study?
Arrhythmia is a cause of death in patients with severe coronary artery disease who also have cancer, but whether new-onset tumor influences arrhythmia incidence was unclear.
Does new-onset tumor increase the incidence of arrhythmia in patients with severe coronary artery disease?
Cross-Sectional (n=79)
No
Does new-onset tumor increase the incidence of arrhythmia in patients with severe coronary artery disease?
Patients with severe coronary artery disease and new-onset cancer have a significantly higher incidence of arrhythmias compared to those with severe CAD alone, highlighting the need for pre-treatment arrhythmia screening in cardio-oncology.
Answers are grounded in this paper and cite their sources.
Supports arrhythmia surveillance in severe CAD with new tumors; leaves open causality and need for prospective trials.
Background. Arrhythmia is one of the causes of death in severe coronary artery disease patients who also suffered from cancer. Our research aims to compare the incidence of arrhythmia between severe coronary artery disease patient with and without new-onset tumor. Methodology. We enrolled 79 patients (December 2019–December 2020) with severe coronary artery disease in this study, and 40 of them were complicated with new-onset tumor. The details of all subjects were thoroughly obtained; the laboratory tests were implemented including creatinine before coronary angiography. The appraisal of the severity of coronary artery disease was applied by Gensini score. The cardiac inspection includes UCG, 12-lead ECG, and Holter monitor. Results. Among them, there were 40 patients in the experimental group and 39 patients in the control group. The difference at the baseline between the two sets of figures was not statistically significant ( <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>P</a:mi> <a:mo>></a:mo> <a:mn>0.05</a:mn> </a:math> ). The incidence of arrhythmia between the two groups was statistically significant ( <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" id="M2"> <c:mi>P</c:mi> <c:mo><</c:mo> <c:mn>0.05</c:mn> </c:math> ). Conclusions. The incidence of arrhythmia in severe coronary artery disease patients who were complicated with new-onset tumor was higher than that in patients with severe coronary artery disease alone, and attention should be paid to arrhythmia before tumor treatment.
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Alimu et al. (2021) conducted a cross-sectional in Severe coronary artery disease (n=79). New-onset tumor vs. Severe coronary artery disease without tumor was evaluated on Incidence of arrhythmia (p=<0.05). The presence of a new-onset tumor in patients with severe coronary artery disease was associated with a higher incidence of arrhythmia compared to patients without a tumor.
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