Why the study?
Does Trpv4 activation by 4αPDD improve collateral vessel growth and conductance in models of arterial occlusion?
Does Trpv4 activation by 4αPDD improve collateral vessel growth and conductance in models of arterial occlusion?
Activation of the shear stress-sensitive channel Trpv4 induces active proliferation of vascular cells and triggers collateral vessel growth, suggesting a potential therapeutic target for arterial occlusive diseases.
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Supports Trpv4 activation for collateral growth in arterial occlusion models; leaves open translation to human disease.
Troidl et al. (2008) studied this question.
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