Why the study?
What are the mechanical correlates of abnormal calcium handling in the hypertrophied human left ventricle?
Population
Patients with severe aortic stenosis and patients with hypertrophic cardiomyopathy
Comparison
Drastic left-ventricular unloading by sequential… vs Baseline/rest conditions
Design
Cohort
Authors
Loading...
May reflect calcium-dependent diastolic dysfunction in hypertrophy; extends mechanistic insights but leaves open clinical implications.
What are the mechanical correlates of abnormal calcium handling in the hypertrophied human left ventricle?
In hypertrophied human hearts, abnormal calcium handling manifests mechanically as slow, dyssynchronous isovolumic relaxation after unloading and diastolic aftercontractions accompanied by delayed afterdepolarizations.
Paulus et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: