Key result
LV pressure overload linked to ~64% longer mechanical restitution recovery time versus volume overload.
Why the study?
Does left ventricular pressure or volume overload alter the mechanical and electrical refractory properties of isolated human ventricular myocardium?
Population
Isolated strips of human ventricular myocardium from 40 patients undergoing cardiac surgery.
Comparison
Ex vivo assessment of mechanical restitution and… vs Comparison between pressure overload, volume…
Design
Preclinical
Authors
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Pressure overload may slow mechanical restitution in hypertrophied myocardium; hypothesis-generating for alternans mechanisms and requires human validation.
Observational (n=40)
Does left ventricular pressure or volume overload alter the mechanical and electrical refractory properties of isolated human ventricular myocardium?
Absolute Event Rate: 603% vs 367%
p-value: p=<0.005
Myocardial hypertrophy due to pressure overload in humans is associated with slowed recovery of mechanical restitution, potentially explaining the occurrence of mechanical alternans.
Cooper et al. (1992) conducted an observational in Left ventricular pressure overload, volume overload, or normal left ventricular function (n=40). Left ventricular pressure overload vs. Volume overload or normal left ventricular function was evaluated on Time constant of the initial rapid recovery phase of mechanical restitution (tau 1) (p=<0.005). Left ventricular pressure overload significantly prolonged the time constant of mechanical restitution recovery (603 ms) compared to volume overload (367 ms) and normal LV function (259 ms; p<0.005).
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