What does this research mean for the field?

A chronic increase in tissue kallikrein expression protects against cardiac ischemia by elevating bradykinin levels, which acts via a rapid, bradykinin type 2 receptor-dependent mechanism. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 8, 2000The FASEB Journal

Increased kallikrein expression protects against cardiac ischemia

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Why the study?

Does increased tissue kallikrein expression protect against cardiac ischemia in an ex vivo rat heart model?

Population

Isolated hearts from transgenic rats harboring the human tissue kallikrein gene TGR and their transgene…

Comparison

Transgenic expression of human tissue kallikrein… vs Transgene negative littermates with or without…

Design

Preclinical

Authors

YPYigal M. PintoHeart Failure & Transplant MBMichael BäderUniversity of Stuttgart JPJoão Bosco PesqueroUniversidade Estadual de Campinas (UNICAMP)

Discussion

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Implication

Supports kallikrein-kinin exploration in cardioprotection; leaves open translation beyond rodent ischemia models.

Structured PICO

Does increased tissue kallikrein expression protect against cardiac ischemia in an ex vivo rat heart model?

Population

Isolated hearts from transgenic rats harboring the human tissue kallikrein gene TGR(hKLK1) and their transgene negative littermates, subjected to ex vivo regional cardiac ischemia and reperfusion.

Intervention

Transgenic expression of human tissue kallikrein (TGR(hKLK1)) with or without co-infusion of the specific bradykinin type 2 receptor antagonist HOE 140 (10^-9 M).

Comparator

Transgene negative littermates with or without co-infusion of HOE 140.

Outcome

Overflow of nucleotide breakdown products upon reperfusion and systolic dP/dt at the end of ischemia.surrogate

A chronic increase in tissue kallikrein protects against cardiac ischemia through a rapid, bradykinin-dependent mechanism.

Cite This Study

Pinto et al. (2000) studied this question.

synapsesocial.com/papers/6a1a0eba05af093a17f6efdb https://doi.org/10.1096/fj.99-1011fje

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Increased kallikrein expression protects against cardiac ischemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased kallikrein expression protects against cardiac ischemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider