Population
Mice subjected to in vivo acute myocardial ischemia
Comparison
Ischemic preconditioning or pharmacological… vs Tissue kallikrein-deficient mice vs wild-type…
Design
Review
Follow-up
3 hours (reperfusion period)
Authors
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Suggests B2 activation for ischemic protection; leaves open translation from rodent models to clinical strategies.
The kallikrein-kinin system, specifically tissue kallikrein and the B2 receptor, plays a crucial role in mediating cardioprotection during acute myocardial ischemia, suggesting B2 receptor activation as a potential therapeutic target.
Messadi‐Laribi et al. (2008) studied this question.
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