October 17, 2005British Journal of PharmacologyOpen Access

A kallidin‐like peptide is a protective cardiac kinin, released by ischaemic preconditioning of rat heart

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Population

Isolated rat hearts (Langendorff model)

Comparison

Ischaemic preconditioning consisting of three 5… vs Control group without ischaemic preconditioning

Design

Preclinical

Authors

XLXiuxin LiuBinzhou University MLMartina LukasovaHeidelberg University RZRadka ZubakovaHeidelberg University

Discussion

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Implication

May support kallidin-like peptide as IPC mediator via B2 receptors in rats; hypothesis-generating for human cardioprotection.

Structured PICO

Population

Isolated rat hearts (Langendorff model)

Intervention

Ischaemic preconditioning (IPC) consisting of three 5 min no-flow and 5 min reperfusion cycles prior to 30 min ischaemia, with or without KAL antibody or HOE140 (kinin B2-receptor antagonist)

Comparator

Control group without ischaemic preconditioning

Outcome

Release of bradykinin and KAL-like peptide in the effluent, and creatine kinase activity as a measure of cardiac injurysurrogate

In isolated rat hearts, ischaemic preconditioning releases a kallidin-like peptide rather than bradykinin, which acts via the kinin B2-receptor to mediate cardioprotection.

Cite This Study

Liu et al. (2005) studied this question.

synapsesocial.com/papers/6a717cb626a7f98052ddd17d https://doi.org/10.1038/sj.bjp.0706402

View Full Paper

Ask AI

Bookmark

A kallidin‐like peptide is a protective cardiac kinin, released by ischaemic preconditioning of rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A kallidin‐like peptide is a protective cardiac kinin, released by ischaemic preconditioning of rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider