June 12, 2006British Journal of PharmacologyOpen Access

Kallidin‐like peptide mediates the cardioprotective effect of the ACE inhibitor captopril against ischaemic reperfusion injury of rat heart

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Why the study?

Does captopril reduce ischaemic reperfusion injury in isolated rat hearts?

Population

Isolated Langendorff rat heart model of ischaemic reperfusion injury

Comparison

Captopril (ACE inhibitor) vs Control group (untreated)

Design

Preclinical

Follow-up

30 min ischaemia and reperfusion

Authors

XLXiuxin LiuBinzhou University MLMartina LukasovaHeidelberg University RZRadka ZubakovaHeidelberg University

Discussion

Member takes

Implication

Supports B2-receptor mediated cardioprotection by captopril in rat hearts; leaves open translation to human ischaemia-reperfusion injury.

Structured PICO

Does captopril reduce ischaemic reperfusion injury in isolated rat hearts?

Population

Isolated Langendorff rat heart model of ischaemic reperfusion injury

Intervention

Captopril (ACE inhibitor)

Comparator

Control group (untreated)

Outcome

Creatine kinase activity after 30 min ischaemia and reperfusion, and kallidin-like peptide levelssurrogate

Captopril mediates cardioprotection against ischaemic reperfusion injury in rat hearts through a kallidin-like peptide acting via the kinin B2 receptor.

Cite This Study

Liu et al. (2006) studied this question.

synapsesocial.com/papers/6a717cb626a7f98052ddd17c https://doi.org/10.1038/sj.bjp.0706799

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Kallidin‐like peptide mediates the cardioprotective effect of the ACE inhibitor captopril against ischaemic reperfusion injury of rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Kallidin‐like peptide mediates the cardioprotective effect of the ACE inhibitor captopril against ischaemic reperfusion injury of rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider