November 1, 1997Hypertension
Sensitivity of Blood Pressure and Renin Activation During Sodium Restriction
Why the study?
Does early renin activation determine the blood pressure response to a sodium-restricted diet in untreated essential hypertensive patients?
Population
67 untreated essential hypertensive patients (analyzable data for n=55) admitted to a metabolic ward
Design
Cohort
Follow-up
8 days
Authors
Discussion
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Implication
Blunted early renin response may identify greater BP response to sodium restriction; leaves open need for randomized confirmation before guiding therapy.
Structured PICO
Does early renin activation determine the blood pressure response to a sodium-restricted diet in untreated essential hypertensive patients?
P
Population
67 untreated essential hypertensive patients (analyzable data for n=55) admitted to a metabolic ward
I
Intervention
Sodium restricted diet of 55 mmol/d from the second to the last day of an 8-day admission
O
Outcome
Interrelationships among cumulative sodium loss, renin activation, and blood pressure changessurrogate
Blood pressure reduction during sodium restriction in essential hypertension is driven more by an early blunted renin response than by total sodium loss.
Cite This Study
Krekels et al. (1997) studied this question.