January 1, 1984Journal of Cardiovascular Pharmacology
Relation of Blood Pressure and Body Sodium Content During Sodium Depletion in Normal and Hypertensive Subjects
Why the study?
Does sodium depletion alter blood pressure and hormonal responses differently in normal versus essential hypertensive men?
Population
17 men (7 normal men and 10 essential hypertensive men of similar age and weight)
Comparison
Sodium depletion produced by 40 mg frusemide and… vs Normal sodium intake of 145-150 mmol/24 h for a…
Follow-up
2 to 3 days per period
Authors
Discussion
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Implication
Differential MAP responses in this small cohort warrant clinical caution; hypothesis-generating for altered pressure natriuresis in hypertension.
Structured PICO
Does sodium depletion alter blood pressure and hormonal responses differently in normal versus essential hypertensive men?
P
Population
17 men (7 normal men and 10 essential hypertensive men of similar age and weight)
I
Intervention
Sodium depletion produced by 40 mg frusemide and a dietary sodium intake less than 10 mmol/24 h for a 2- to 3-day period
C
Comparator
Normal sodium intake of 145-150 mmol/24 h for a 2- to 3-day period
O
Outcome
Changes in mean arterial pressure, exchangeable sodium content, sodium metabolic balance, and plasma concentrations of active renin, angiotensin II, and aldosteronesurrogate
Sodium depletion decreases mean arterial pressure in hypertensive men but increases it in normotensive men, suggesting an altered pressure natriuresis mechanism in hypertension.
Cite This Study
Fräser et al. (1984) studied this question.