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September 1, 1998Archives of Neurology

Factors independently associated with lacunes included increased age, diastolic blood pressure, creatinine, pack-years of smoking (all P < .005), internal carotid artery stenosis >50% (OR 1.81, P < .005), male sex (OR 0.74, P < .005), and diabetes (OR 1.33, P < .05).

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Population

3660 adults aged 65 years or older participating in the Cardiovascular Health Study who underwent cranial MRI.

Design

Cross-sectional, Neuroradiologists read scans in a standard fashion without…

Authors

WLW. T. LongstrethBrigham Young University

Discussion

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Overview

Highlights modifiable risks for lacunes in older adults; leaves open causality and preventive impact pending longitudinal studies.

Structured PICO

P
Population
3660 adults aged 65 years or older participating in the Cardiovascular Health Study who underwent cranial MRI.
O
Outcome
Risk factors for and functional consequences of lacunar infarcts defined by MRI

In older adults, MRI-defined lacunar infarcts are common, often silent, associated with small-vessel disease risk factors, and linked to unrecognized neurologic dysfunction.

Cite This Study

W. T. Longstreth (1998) studied this question.

synapsesocial.com/papers/6a1a20971d4d911c80ead3c2https://doi.org/10.1001/archneur.55.9.1217
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