Why the study?
Does flunarizine antagonize calcium-dependent endothelial stimulation (relaxation and cGMP increase) in rat isolated aorta?
Population
Rat isolated aorta segments complete with endothelium
Comparison
Flunarizine and/or calcium-free solution, with… vs Absence of flunarizine / presence of calcium
Design
Preclinical
Authors
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Flunarizine does not inhibit endothelial cGMP increases in rat aorta; leaves open distinct endothelial calcium channel pharmacology versus smooth muscle.
Does flunarizine antagonize calcium-dependent endothelial stimulation (relaxation and cGMP increase) in rat isolated aorta?
In rat aorta, endothelium-dependent relaxation and cGMP increases require extracellular calcium but are not antagonized by the calcium channel blocker flunarizine, suggesting endothelial calcium channels differ from smooth muscle calcium channels.
Miller et al. (1985) studied this question.
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