Key result
Oral estradiol treatment initiated early after ovariectomy in female monkeys enhanced LV diastolic function and altered expression of 40 myocardial genes (>1.2-fold change; P<0.05).
Why the study?
Does oral estradiol initiated early after ovariectomy improve LV diastolic function and regulate myocardial gene expression in female cynomolgus macaques?
Population
Ovariectomized female cynomolgus macaques
Comparison
Oral estradiol at a human-equivalent dose of 1… vs Placebo (control)
Design
Preclinical, Randomized
Follow-up
8 months
Authors
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May support diastolic benefits in primates; leaves open clinical translation to women pending human trials.
RCT
Does oral estradiol initiated early after ovariectomy improve LV diastolic function and regulate myocardial gene expression in female cynomolgus macaques?
p-value: p=<0.05
In a primate model, estradiol treatment initiated early after ovariectomy enhanced LV diastolic function and favorably altered myocardial gene expression related to calcium homeostasis and extracellular matrix remodeling.
Michalson et al. (2018) conducted an RCT in LV diastolic dysfunction. Oral estradiol vs. Placebo was evaluated on LV function and myocardial gene expression (p=<0.05). Oral estradiol treatment initiated early after ovariectomy in female monkeys enhanced LV diastolic function and altered expression of 40 myocardial genes (>1.2-fold change; P<0.05).
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