Why the study?
Does ischaemic preconditioning protect the myocardium during off-pump coronary artery bypass grafting?
Does ischaemic preconditioning protect the myocardium during off-pump coronary artery bypass grafting?
This review explores the role of ischaemic preconditioning as an endogenous cardioprotective mechanism during off-pump coronary artery bypass grafting.
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Ischaemic preconditioning's role in off-pump CABG remains exploratory; leaves open clinical utility pending prospective trials.
Short periods of ischaemia consecutive to reperfusion periods before a sustained ischaemic condition, the so-called ischaemic preconditioning (IP), aim to protect myocardial cells against prolonged ischaemia. IP appears as a considerable endogenous cardioprotective mechanism decreasing the infarct size after total occlusion in either experimental models or humans. Angina periods before an acute coronary syndrome limit the myocardial infarction being protective for the myocardium. Our report aims to review the international bibliography of the IP during off-pump coronary artery bypass grafting.
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Apostolakis et al. (2011) studied this question.
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