Statistical ranking of electromechanical dyssynchrony parameters for CRT

Figures

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  Figure 1. (A) AV dyssynchrony due to long PR. Aortic ejection and left diastolic filling flows timings represented according to the ECG tracing. Observe the fusion between the protodiastolic E wave with the atrial contribution A leading to filling duration decrease. (B) AV dyssynchrony due to intraV dyssynchrony. Same reduction in filling phase duration phenomenon as observed above but due to delayed timing of aortic ejection flow because of prolongation of LPEI. AV, atrioventricular; DFT, diastolic filling time; intraV, intraventricular; LPEI, left pre-ejection interval.

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  Figure 2. (A) AV and interV synchrony: description of the variables of the model. (B) IntraV dyssynchrony parameters. AV, atrioventricular; DFT, diastolic filling time; interV, interventricular; intraV, intraventricular; IVD, interventricular delay; IsovolCT, isovolumic contraction time; IsovolRT, isovolumic relaxation time; LLW, left lateral wall; LPEI, left pre-ejection interval; LVET, left ventricular ejection time; MVC, mitral valve closure; RPEI, right pre-ejection interval; SD, systole duration; Sept, septal.

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  Figure 3. Variance not captured by the K selected variables in the best, median and worst cases. The x axis represents the number of selected variables (K), the y axis shows the percentage of variance not captured by these K variables. For each number of selected variables, the algorithm computed 18 groups of variables, corresponding to the 18 initially selected variables. For each K, the best set is represented in green, the median in orange and the worst in blue. As an example, for K=2, the blue line shows that the best set captures more or less 40% of the variance of the dataset.

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  Figure 4. Different levels of correlation between electromechanical parameters. Each set of electromechanical parameters represents the correlations between these parameters at different levels of correlation (0,1; 0,5; 0,7). Increasing correlation defines different subgroups of variables. The last panel (C) shows three subgroups of highly correlated variables, in which one variable can describe the others in the subgroup. DFT, diastolic filling time; IsovolCT, isovolumic contraction time; IsovolRT, isovolumic relaxation time; LLW, left lateral wall; LPEI, left pre-ejection interval; LVET, left ventricular ejection time; MVR, mitral valve regurgitation; RPEI, right pre-ejection interval; SD, systole duration; Sept, septal.