Why the study?
The differential roles of mechanosensitive and chemosensitive afferent renal nerves in the reno-renal reflex promoting natriuresis, sympathoinhibition, and normotension during acute and chronic challenges to sodium homeostasis remained unclear.
Does selective afferent renal nerve ablation alter natriuresis and blood pressure regulation in response to salt loading in rats?
Population
Sprague-Dawley, Dahl salt-resistant, and Dahl salt-sensitive rats
Comparison
Selective afferent renal nerve ablation vs sham procedure
Design
Animal experimental study
Authors
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No immediate clinical implications from rat data; leaves open afferent renal nerve contributions to human salt-sensitive hypertension.
Does selective afferent renal nerve ablation alter natriuresis and blood pressure regulation in response to salt loading in rats?
Mechanosensitive afferent renal nerves mediate an acute sympathoinhibitory natriuretic reflex and protect against the development of salt-sensitive hypertension in rat models.
Frame et al. (2019) studied this question.
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