Key result
Combined administration of rauwolscine and losartan enhanced afferent renal nerve activity responses to reflex increases in efferent renal sympathetic nerve activity in rats on a low-sodium diet.
Why the study?
Does alpha-2 adrenoceptor blockade alter the afferent renal nerve activity response to efferent renal sympathetic nerve activity in rats on low- or high-sodium diets?
Population
131 male Sprague-Dawley rats weighing 202-464 g, fed either a low-sodium diet or high-sodium diet for two…
Comparison
Renal pelvic administration of rauwolscine… vs Vehicle administration.
Design
Preclinical, random order (for drug administration in specific protocols)
Authors
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Hypothesis-generating in low-sodium rats; leaves open whether alpha-2/AT1 blockade modulates human renorenal reflexes.
Does alpha-2 adrenoceptor blockade alter the afferent renal nerve activity response to efferent renal sympathetic nerve activity in rats on low- or high-sodium diets?
Absolute Event Rate: 4680% vs 2220%
p-value: p=<0.01
Increased activation of alpha-2 adrenoceptors contributes to the reduced interaction between efferent and afferent renal nerve activity during low-sodium intake, whereas minimal activation contributes to the enhanced interaction during high-sodium intake.
Kopp et al. (2010) studied Dietary sodium modulation of renal nerve activity (n=131). Rauwolscine and Losartan vs. Vehicle or single agent was evaluated on Afferent renal nerve activity (ARNA) response to reflex increases in efferent renal sympathetic nerve activity (ERSNA) (p=<0.01). Combined administration of rauwolscine and losartan enhanced afferent renal nerve activity responses to reflex increases in efferent renal sympathetic nerve activity in rats on a low-sodium diet.
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