August 15, 2000Circulation

Increased Activity of Nuclear Factor-κB Participates in Cardiovascular Remodeling Induced by Chronic Inhibition of Nitric Oxide Synthesis in Rats

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Why the study?

Does in vivo transfection of cis element decoy oligodeoxynucleotides against NF-kappaB prevent cardiovascular remodeling in rats treated with L-NAME?

Population

Rats with cardiovascular remodeling induced by chronic administration of N-nitro-L-arginine methyl ester

Design

Preclinical

Authors

Discussion

NF-κB decoy may limit early vascular inflammation in NO-deficient models; leaves open its role in fibrosis and clinical translation.

Does in vivo transfection of cis element decoy oligodeoxynucleotides against NF-kappaB prevent cardiovascular remodeling in rats treated with L-NAME?

Population

Rats with cardiovascular remodeling induced by chronic administration of N(omega)-nitro-L-arginine methyl ester (L-NAME)

Intervention

In vivo transfection of cis element decoy oligodeoxynucleotides against NF-kappaB to hearts

Outcome

Early inflammation and subsequent coronary vascular medial thickeningsurrogate

NF-kappaB participates in early vascular inflammation and medial thickening, but not fibrogenesis, in a rat model of chronic NO synthesis inhibition.

Kitamoto et al. (2000) studied this question.

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