Why the study?
Does pre-hospital fibrinolysis reduce mortality in patients with ST-elevation myocardial infarction?
Does pre-hospital fibrinolysis reduce mortality in patients with ST-elevation myocardial infarction?
Timely pre-hospital fibrinolysis reduces 1-month mortality in STEMI patients, and subsequent coronary intervention provides additional benefit.
Reinforces timely pre-hospital fibrinolysis in STEMI protocols; leaves open the incremental benefit of each component.
AIMS: To review existing evidence on the role of pre-hospital fibrinolysis in patients with ST-elevation myocardial infarction (MI). METHODS AND RESULTS: Overview of current guidelines and data from trials and registries on the best perfusion approach for acute MI with ST-elevation. Despite advances in the treatment of ST-elevation MI, the mortality rate before any therapy is administered is high, with half of all fatalities occurring within 2 h of symptom onset. Current treatment options, including the timely use of pre-hospital fibrinolysis, have reduced the overall 1 month mortality. Mortality can be further improved when patient characteristics, risk factors and time delays to treatment are considered. CONCLUSION: Time factors are essential in the success of fibrinolysis, and subsequent coronary intervention seems beneficial.
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Danchin et al. (2008) studied this question.
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