Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 30, 2026Cancer BiomarkersOpen Access

Stage-specific biomarkers in triple-negative breast cancer: Preliminary findings from bioinformatics approaches

View Full Paper
Ask AI
Bookmark
Share

Authors

FSFaeze ShahrakiAMAzadeh MeshkiniENE L H A M Nazari

Discussion

Loading...

Member takes

Overview

Bioinformatics approaches reveal novel biomarkers and drug targets in triple-negative breast cancer across stages, indicating new therapies.

Key Points

  • This research aims to identify stage-specific biomarkers and potential drug targets in triple-negative breast cancer using bioinformatics.
  • Analyzed microarray and RNA-seq datasets from various stages of TNBC and normal samples.
  • Identified differentially expressed genes (DEGs) followed by co-expression analysis using Weighted Gene Co-expression Network Analysis (WGCNA).
  • Conducted molecular docking to assess potential therapeutic agents.
  • Identified novel biomarkers such as DNAJC6 and F11R in early-stage and advanced-stage TNBC, respectively.
  • UALCAN analysis confirmed the dysregulation of these genes across 23 malignancies.
  • Docking analysis highlighted doxorubicin and sunitinib as potential therapeutic agents.

Cite This Study

Shahraki et al. (2026) studied this question.

synapsesocial.com/papers/6a1a816c0307b78509433553https://doi.org/10.1177/18758592261454886
View Full Paper
Ask AI
Bookmark
Share