Key result
EV-D68 subclade B3 is linked to higher oxygen requirement vs subclade D1 in hospitalized children.
Why the study?
Increased circulation of enteroviruses from July to December 2024 motivated an evaluation of hospitalized children with acute respiratory infections.
Observational (n=23,245)
Answers are grounded in this paper and cite their sources.
An epidemic of EV-D68 with co-circulation of B3 and D1 subclades occurred in Beijing in 2024, with the B3 subclade associated with more severe respiratory disease requiring oxygen supplementation.
The increased circulation of enteroviruses (EVs) from July to December 2024 necessitated a retrospective analysis of hospitalized children with acute respiratory infections in Beijing, China, during 2017-2024. Among the 155 cases confirmed as EVs (0.67%, 155/23,245), with peaks in a triennial pattern and predominance between July and October, 114 were EV-D68, with 82 (71.93%) detected between July and October 2024. Among the 79 VP1 gene sequences of EV-D68 classified into subclades B3 (50.63%, 40/79) and D1 (49.37%, 39/79) through phylogenetic analysis, 31 (77.50%, 31/40) were B3 from 2024, and 34 (87.18%, 34/39) were D1 from 2024. More patients infected with B3 required oxygen supplementation than those infected with D1 (p = 0.042). Therefore, an epidemic of EV-D68 with the co-circulation of B3 and D1 was observed in 2024, with more severe disease caused by B3 than by D1, which underscores the urgent need for surveillance of EV-D68.
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Hanhaoyu et al. (2026) conducted an observational in Acute respiratory infections (n=23,245). EV-D68 subclade B3 vs. EV-D68 subclade D1 was evaluated on Requirement for oxygen supplementation (p=0.042). Infection with EV-D68 subclade B3 was associated with a higher requirement for oxygen supplementation compared to subclade D1 among hospitalized children.
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