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June 27, 2002Acta Physiologica Scandinavica

Gene expression of colony‐stimulating factors and stem cell factor after myocardial infarction in the mouse

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Population

Mouse model of myocardial infarction induced by ligation of the left coronary artery

Comparison

Myocardial infarction via left coronary artery… vs Sham operation

Design

Preclinical

Authors

PWPer Reidar WoldbækUniversity of OsloIHIngvild B HoenOslo University HospitalGCGeir ChristensenHeart Failure & Transplant

Discussion

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Implication

Does not inform clinical practice; leaves open M-CSF/SCF roles in ischemic HF pathogenesis.

Structured PICO

P
Population
Mouse model of myocardial infarction induced by ligation of the left coronary artery
I
Intervention
Myocardial infarction via left coronary artery ligation
C
Comparator
Sham operation
O
Outcome
mRNA expression of M-CSF, GM-CSF, SCF, IL-3 and IL-7surrogate

M-CSF and SCF gene expression are down-regulated in the heart and other organs following myocardial infarction in mice, suggesting a role in ischemic heart failure development.

Cite This Study

Woldbæk et al. (2002) studied this question.

synapsesocial.com/papers/6a1a8f7fe916fa6dd3b8bdabhttps://doi.org/10.1046/j.1365-201x.2002.00989.x

Topics

Heart failureHFrEF treatment
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Also Consider

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  1. 1Altered plasma levels of cytokines in patients with ischemic heart disease1997 · 57 citations
  2. 2Increased cardiac expression of endothelin-1 mRNA in ischemic heart failure in rats1997 · 73 citations
  3. 3Chronic myocardial infarction in the mouse: cardiac structural and functional change1999 · 182 citations
  4. 4Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat2000 · 301 citations
  5. 5CSF-1 signal transduction1997 · 206 citations