Why the study?
Does long-term antihypertensive treatment reduce the risk of dementia and cognitive decline in older hypertensive men?
Population
Japanese American men from the Honolulu Asia Aging Study, hypertensive from midlife and dementia-free in…
Comparison
Antihypertensive treatment of varying durations. vs Never-treated hypertensives and normotensive…
Design
Cohort
Follow-up
Assessments in 1991, 1994, and 1997
Authors
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Should not yet change practice for dementia prevention; leaves open whether long-term antihypertensives causally reduce risk in RCTs.
Does long-term antihypertensive treatment reduce the risk of dementia and cognitive decline in older hypertensive men?
Long-term antihypertensive treatment (>12 years) in older men is associated with a significantly reduced risk of incident dementia and Alzheimer's disease, comparable to the risk in normotensive individuals.
Peila et al. (2006) studied this question.
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