Why the study?
Is insulin resistance specifically associated with essential hypertension compared to secondary causes of hypertension?
Is insulin resistance specifically associated with essential hypertension compared to secondary causes of hypertension?
Essential hypertension is associated with significant insulin resistance compared to secondary hypertension, suggesting a specific pathophysiological link between insulin resistance and essential hypertension.
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Supports specific insulin resistance link in essential hypertension; hypothesis-generating and should not yet change practice.
The insulin sensitivity of five essential hypertensive patients was compared to five patients with renovascular hypertension, five patients with primary hyperaldosteronism, and five normotensive subjects, using the euglycemic hyperinsulinemic clamp technique. Essential hypertensive patients had significantly lower insulin sensitivity than patients with hyperaldosteronism and renovascular hypertensive patients (P = .0066, P = .004, respectively). Hyperaldosteronism patients also had less insulin sensitivity than renovascular hypertensive patients (P = .016). A significant negative correlation was found between body mass index and insulin sensitivity index for essential hypertension patients only (r = -0.87, P less than .003). No such correlation was found in the secondary hypertension patients. The findings suggest a causal relationship between insulin resistance and the development of essential hypertension. Secondary hypertension, on the other hand, is not such an insulin resistant state.
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Shamiss et al. (1992) studied this question.
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