Key result
Primary hyperaldosteronism is linked to ~36% lower glucose disposal rate versus healthy controls.
Why the study?
There are sparse data regarding the presence of insulin resistance in patients with secondary hypertension such as primary hyperaldosteronism.
Population
12 patients with primary hyperaldosteronism
Comparison
Patients with primary hyperaldosteronism vs healthy control subjects
Design
Case-control study using hyperinsulinemic euglycemic clamp technique
Authors
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Hypothesis-generating for insulin resistance in primary hyperaldosteronism; prospective studies needed before clinical implications.
Case-Control
Absolute Event Rate: 18.7% vs 29.3%
Patients with primary hyperaldosteronism exhibit insulin resistance, indicating that impaired insulin action is also a feature of secondary hypertension.
Jr. et al. (2000) conducted a case-control in Primary hyperaldosteronism. Primary hyperaldosteronism vs. Normal control subjects was evaluated on Glucose disposal rate (M, micromol/kg/min). Primary hyperaldosteronism was associated with a significantly lower glucose disposal rate compared to healthy controls (18.7 vs. 29.3 micromol/kg/min).
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