Aldosterone Excess Impairs First Phase Insulin Secretion in Primary Aldosteronism

22 patients with primary aldosteronism (unilateral aldosterone-producing adenoma and bilateral idiopathic adrenal hyperplasia), 11 patients with essential hypertension, and 11 normotensive controls. A subgroup of 9 patients with aldosterone-producing adenoma underwent prospective follow-up.

Unilateral adrenalectomy (in 9 patients with aldosterone-producing adenoma)

Pre-adrenalectomy baseline, as well as essential hypertension and normotensive control groups

First-phase insulin reaction in intravenous glucose tolerance testsurrogate