Why the study?
Does surgical or pharmacological treatment of primary hyperaldosteronism improve insulin sensitivity?
Population
9 patients with arterial hypertension caused by primary hyperaldosteronism
Comparison
Surgical removal of aldosterone producing… vs Healthy controls and pre-treatment values
Design
Cohort
Follow-up
at least 6 months
Authors
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Surgery-associated insulin sensitivity gains versus spironolactone support differential effects; hypothesis-generating and require randomized confirmation before practice change.
Does surgical or pharmacological treatment of primary hyperaldosteronism improve insulin sensitivity?
Surgical removal of aldosterone-producing adenomas, but not spironolactone therapy, normalizes plasma aldosterone and improves insulin sensitivity, suggesting aldosterone directly impairs insulin action.
Šindelka et al. (2012) studied this question.
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