Key result
Primary aldosteronism subtypes are linked to impaired glucose tolerance or diabetes in up to ~52% of patients.
Why the study?
Primary aldosteronism is associated with an increased risk of diabetes mellitus, but whether the pathogenesis of glucose intolerance differs between primary aldosteronism subtypes was unclear.
Does the pathogenesis of glucose intolerance differ between aldosterone-producing adenoma and idiopathic hyperaldosteronism in patients with primary aldosteronism?
Population
116 patients diagnosed with primary aldosteronism who underwent adrenal venous sampling
Comparison
Aldosterone-producing adenoma vs idiopathic hyperaldosteronism
Design
Observational study
Authors
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Supports differential glucose intolerance mechanisms by primary aldosteronism subtype; hypothesis-generating for tailored management.
Observational (n=116)
Does the pathogenesis of glucose intolerance differ between aldosterone-producing adenoma and idiopathic hyperaldosteronism in patients with primary aldosteronism?
Absolute Event Rate: 46.4% vs 52.3%
Insulin secretion impairment drives glucose intolerance in aldosterone-producing adenoma, whereas insulin resistance drives it in idiopathic hyperaldosteronism, with treatment improving glucose tolerance more effectively in non-obese patients.
Okazaki‐Hada et al. (2020) conducted an observational in Primary aldosteronism (n=116). Aldosterone-producing adenoma vs. Idiopathic hyperaldosteronism was evaluated on Impaired glucose tolerance or diabetes. Aldosterone-producing adenoma and idiopathic hyperaldosteronism were associated with impaired glucose tolerance or diabetes in 46.4% and 52.3% of patients, respectively.
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